Publications

Structural approaches to pathway specific antimicrobial agents  Johnson, Michael E, Fung, LW-M  Translational Research, in press (March, 2020); www.translationalres.com/inpress

Determination of absolute configuration and binding efficacy of benzimidazole-based FabI inhibitors through the support of electronic circular dichroism and MM-GBSA techniques   Ren J, Mistry TL , Su P-C,  Mehboob S, Demissie R, Fung LW-M, Ghosh AK,  Johnson ME  Bioorg Med Chem Lett., 2018; 28: 2074-2079  PMID: 29730028; doi: org/10.1016/j.bmcl.2018.04.052

Identification of B. anthracis N(5)-carboxyaminoimidazole ribonucleotide mutase (PurE) active site binding compounds via fragment library screening. Lei H, Jones C, Zhu T, Patel K, Wolf NM, Fung LW-M, Lee H, Johnson ME.        Bioorg Med Chem. 2016; 24:596-605.  PubMed PMID: 26740153.

Substrate independent ATPase activity may complicate high throughput screening.  Tuntland ML, Fung LW-M.  Analytical biochemistry. 2016; 510:18-20. NIHMSID: NIHMS805819  PubMed [journal]PMID: 27430931 PMCID: PMC4980188

An Efficient and Economical Assay to Screen for Triclosan Binding to FabI.
Demissie RD, Kabre P, Tuntland ML, Fung LW-M.
Journal of biomolecular screening. 2016; 21(4):391-8.
PubMed [journal]PMID: 26538431

Identification of B. anthracis N(5)-carboxyaminoimidazole ribonucleotide mutase (PurE) active site binding compounds via fragment library screening.
Lei H, Jones C, Zhu T, Patel K, Wolf NM, Fung LW-M, Lee H, Johnson ME.
Bioorganic & medicinal chemistry. 2016; 24(4):596-605.
PubMed [journal]PMID: 26740153

Differences in the purification and solution properties of PurC gene products from Streptococcus pneumoniae and Bacillus anthracis.
Tuntland ML, Wolf NM, Fung LW-M.
Protein expression and purification. 2015; 114:143-8.
PubMed [journal]PMID: 26118696

Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity.
Kim A, Wolf NM, Zhu T, Johnson ME, Deng J, Cook JL, Fung LW-M.
Bioorganic & medicinal chemistry. 2015; 23(7):1492-9.
PubMed [journal]PMID: 25737087

Full Publication List